2006 Issues

February 2006 Volume 13 Issue 1

Comparison of Drug Release from Metoprolol Modified Release Dosage Forms in Single Buffer versus a pH-Gradient Dissolution Test Sandra Klein and Jennifer B. Dressman Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main,GERMANY A Novel Multicompartment Dissolution Apparatus for Evaluation of Floating Dosage Form Containing Poorly Soluble Weakly Basic Drug Dr. Rajesh K. Parikh,Dhaivat C. Parikh, Renish R. Delvadia, and Sanjay M. Patel Department of Pharmaceutics and Pharmaceutical Technology, L. M.College of Pharmacy, Ahmedabad ñ 380 009, Gujarat, INDIA Comparative Assessment of Different Dissolution Apparatus for Floating Drug Delivery Systems Atul D. Karande and Pramod G.Yeole Department of Pharmaceutics, Institute of Pharmaceutical Education and Research, Maharashtra, INDIA Comparative Impact of Stirring and Shearing in Drug Dissolution Testing with USP Paddle and Crescent-Shaped Spindles Saeed A. Qureshi Banting Research Centre,Tunneyís Pasture,Ottawa,Ontario, CANADA Book Review: Handbook of Dissolution Testing, 3rd edition FDA Update AAPS Focus Group USP News Question & Answer Section Margareth Marques and William Brown United States Pharmacopeia, Rockville,MD Letter to the Editor

May 2006 Volume 13 Issue 2

Challenges to the Dissolution Test, including Equipment Calibration Vivian Gray V.A. Gray Consulting, Inc, Hockessin, DE From Microstructures of Tablets and Granules to Their Dissolution Behaviour Xiaodong Jia1,2 and Richard A.Williams1 1. Institute of Particle Science and Engineering, School of Process, Environmental and Materials Engineering, University of Leeds, Leeds LS2 9JT,UK 2. Structure Vision Ltd, Leeds Innovation Centre, Leeds LS2 9DF,UK An Interview with Professor Patrick DeLuca and Dr. Susan D'Souza on a Novel In Vitro Technique Vivian Gray Research Editor,Dissolution Technologies Inc.,Hockessin, DE Book Review: Pharmaceutical Dissolution Testing, Edited by Jennifer Dressman and Johannes Kr�mer Tahseen Mirza, Ph.D. Novartis Pharmaceuticals, East Hanover, NJ Question & Answer Section Margareth Marques and William Brown United States Pharmacopeia, Rockville,MD

August 2006 Volume 13 Issue 3

Analytical Method Selection for Drug Product Dissolution Testing Qingxi Wang,Decheng Ma, and John P. Higgins1 Merck Research Laboratories,West Point, PA Evaluation of the Sensitivity of USP Prednisone Tablets to Dissolved Gas in the Dissolution Medium Using USP Apparatus 2 Pallavi Nithyanandan,Gang Deng,William Brown, Ronald Manning, and Samir Wahab USP, Rockville,MD A Comparison of USP Paddle With Crescent-Shaped Spindle Dissolution Profiles Suzanne Spagnoli and Marie Di Maso Merck Frosst Canada & Co., Kirkland,Quebec, Canada Highlights of the AAPS Workshop on Dissolution Testing for the 21st Century Jan Parker1 and Vivian Gray2 1. Lancaster Laboratories, Lancaster, PA 2. V. A. Gray Consulting,Hockessin, DE Question & Answer Section Margareth Marques and William Brown United States Pharmacopeia, Rockville,MD

November 2006 Volume 13 Issue 4

The Mini Paddle Apparatusña Useful Tool in the Early Developmental Stage? Experiences with Immediate-Release Dosage Forms Sandra Klein Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main GERMANY Dissolution Profiles of Three Brands of Lamivudine and Zidovudine Combinations in the Nigerian Market N. A. Ochekpe, N.C. Ngwuluka, H.Owolayo,T. Fashedemi Faculty of Pharmaceutical Sciences, University of Jos, Jos, NIGERIA. Developing Discriminatory Drug Dissolution Tests and Profiles: Some Thoughts for Consideration on the Concept and Its Interpretation Saeed A. Qureshi, Ph.D. Bureau of Pharmaceutical Sciences,Therapeutic Products Directorate, Health Products and Food Branch, Health Canada Ottawa, CANADA Question & Answer Section Margareth Marques and William Brown United States Pharmacopeia, Rockville,MD