November 2011 Volume 18 Issue 4

Hydrodynamic Complexity Induced by the Pulsing Flow Field in USP Dissolution Apparatus 4 Deirdre M. D'Arcy1, Bo Liu1, Tim Persoons2, and Owen I. Corrigan1 1School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland 2Department of Mechanical and Manufacturing Engineering, Trinity College Dublin, Dublin, Ireland Flow-Through Cell Method and IVIVR for Poorly Soluble Drugs Catharina Wähling, Christian Schröter, and Andrea Hanefeld Merck KGaA, CMC Development, Darmstadt, Germany Biorelevant Dissolution Testing of Drug-Eluting Stents: Experiences with a Modified Flow-Through Cell Setup Anne Seidlitz1, Stefan Nagel1, Beatrice Semmling1, Niels Grabow2, Katrin Sternberg2, and Werner Weitschies1 1Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, EMA University of Greifswald, Germany 2Institute for Biomedical Engineering, University of Rostock, Germany A Novel Method for the Elution of Sirolimus (Rapamycin) in Drug-Eluting Stents M. Merciadez, L. Alquier, R. Mehta, A. Patel, and A. Wang Cordis, A Johnson & Johnson Company, Warren, NJ USA Review of Research Paper: Development of a Performance Verification Test for USP Apparatus 4 Erika S. Stippler US Pharmacopeial Convention, Rockville, MD USA Flow-Through Cell Apparatus (USP Apparatus 4): Operation and Features Nikoletta Fotaki Department of Pharmacy & Pharmacology, University of Bath, Bath, UK FIP/AAPS Joint Workshop Report: Dissolution/In Vitro Release Testing of Novel/Special Dosage Forms Cynthia K. Brown1, Horst Dieter Friedel2, Amy R. Barker1, Lucinda F. Buhse3, Susanne Keitel4, Todd L. Cecil5, Johannes Kraemer6, J. Michael Morris7, Christos Reppas8, Mary P. Stickelmeyer1, Chikako Yomota9, and Vinod P. Shah10 1Eli Lilly and Company, Indianapolis, Indiana, USA 2Bayer HealthCare AG, Berlin, Germany 3Food and Drug Administration/CDER/OPS, St. Louis, Missouri, USA 4EDQM, Council of Europe, Strasbourg, France 5United States Pharmacopeia, Rockville, Maryland, USA 6PHAST, Homburg, Germany 7Irish Medicines Board, Dublin, Ireland 8National & Kapodistrian University of Athens, Panepistimiopolis, Greece 9National Institute of Health Science, Tokyo, Japan 10FIP Scientific Secretary, The Hague, Netherlands Question & Answer Section Margareth Marques and William Brown United States Pharmacopeia, Rockville,MD