Industry News May 2015

Combined with Three-Speed Controls and Dynamic Camera Views, Logan Instruments Corp. Adds a New Feature of an Airbath to Its Latest Dissolution System

By Jensen Lee

Somerset, NJ—April 10, 2015—With the emergence of camera dissolution systems within the industry, Logan Instruments Corp. has developed a brand new in-house camera system with a new Airbath Dissolution Tester. The “AIRBATH” system optimizes the use of the cameras while eliminating the need for a standard circulating water bath.

For USP Apparatus 1, the cameras are located in the basket shafts. This allows footage to be recorded within each basket during the test.

For USP Apparatus 2, the new camera dissolution system records footage from the bottom of the AIRBATH dissolution vessels since most tablets remain on the bottom of the vessel during dissolution. This also provides 180-degree views to see particles floating around the paddles.

Along with the camera system, the AIRBATH dissolution tester is able to run up to three different speeds at a time. This 12-position dissolution apparatus will have varying speeds (25-250 rpm) for three groups of four vessels but does not need a water heater/circulator. This feature along with the camera system will provide more information for the pharmaceutical industry than was ever before possible. Logan Instruments Corp. is currently seeking U.S. Patent protection for the in-house camera system with a new Airbath Dissolution Tester and variations thereof.

Please keep an eye out for Logan Instruments Corp. at these industry events: Transdermal and Intradermal Drug Delivery Systems 2015: May 11-12, 2015, in Philadelphia, PA. Achema: June 15-19, 2015, in Frankfurt, Germany. AAPS Annual Meeting: October 25-29, 2015, in Orlando, FL.

For more information, please contact us at info@loganinstruments.com.

Fiber Optic Dissolution Now Available from Hanson Research

Pion Collaboration Provides Customers with In Situ Dissolution Monitoring

Los Angeles, CA—April 29, 2015—Hanson Research, the pioneer of dissolution and diffusion equipment, announced today a collaboration with Pion Inc. to offer fiber optic dissolution monitoring for dissolution labs around the world.

“Customer success is Hanson Research’s number one priority,” stated Royal Hanson, CEO of Hanson Research. “Partnering with a proven company such as Pion guarantees dissolution labs with the durability of Hanson dissolution test instruments and the speed and reproducibility of Pion fiber optic systems.”

This collaboration provides customers with in situ UV monitoring for compendial USP apparatus types, small volume configurations, in situ kinetic solubility, and supersaturation monitoring. UV spectra are read every two seconds from any type of dissolution vessel from pure API, formulations, and finished QC products.

ABOUT HANSON RESEARCH

Hanson Research Corporation is the longest-running engineering firm to specialize in dissolution and diffusion test technology. Founded in 1951 by the innovator of the world’s first dissolution tester, Hanson provides over half a century of research, service, and expertise in designing premium test equipment for QC and R&D labs in six continents worldwide. For more information, please visit hansonresearch.com.

ABOUT PION

Pion Inc. develops and manufactures patented high precision UV fiber optic instruments that provide quality data for flux and dissolution profiling. Pion’s team of scientists are experts in the area of physical chemical property measurement including solubility, permeability (PAMPA), lipophilicity, and ionization. Through a suite of innovative instrumentation, assays, and CRO services, Pion has been providing cutting-edge solutions to the drug development industry for close to 20 years.

CONTACT

Sara Hanson
Hanson Research Corporation
T. 818.882.7266 x339
F. 818.280.0831
pr@hansonresearch.com

dissoGUARD®

The First Dissolution Surveillance Camera System that Helps You Guard Your Results!

Dissolution Accessories is proud to introduce the dissoGUARD®, a dissolution surveillance system, which is now available for most dissolution testers regardless of their manufacturer.

Dissolution Accessories is a family-owned company founded in 1997 in The Netherlands. Our vision is to develop and deliver the highest quality in comprehensive parts, consumables, and accessories in compliance with USP, EP, JP, and associated pharmacopeia. As stated in the U.S. Pharmacopeia General Chapter <1092>, which details the dissolution procedure, “visual observations are often helpful for understanding the source of the variability and whether the dissolution test itself is contributing to the variability.”

Observations: The dissoGUARD® dissolution surveillance system (DSS) gives you the chance to visually observe all your measurements continuously. It combines a unique approach to the visual dissolution testing process and offers important insight at each stage of the pharmaceutical product development process.

Qualifications: The dissoGUARD® allows you to view the rpm of your paddle or basket before, during, and after the measurement. It shows you the wobble when present; it gives you an overview of the conditions of your measurement and behavior of the sample, and stores a video of every measurement for further analysis if there are any concerns about the result.

Recording: The dissoGUARD® software allows you to review all events that occur during the measurements. The videos or snapshots can be marked with key events such as dosage introduction, sample drop, sampling, or unusual behavior and are easily exported for sharing or documentation purposes.

The Dissolution Accessories dissoGUARD® is available in several configurations with cameras precisely placed underneath the dissolution bath of your choice in the exact center of the paddle/basket spinning axis. With state-of-the-art hardware, high-speed communication links, and powerful video-processing algorithms, dissoGUARD® is revolutionizing the dissolution testing environment.

The dissoGUARD® is capable of capturing vital information that was previously unattainable. The unique camera system placed beneath each individual vessel shows the user real-time videos, detects paddle/basket motion, and store videos for further analysis or fault detection that can be reviewed at a convenient moment.

With some unique features such as motion detector and LED illumination, it is able to record good quality videos for all vessels. After recording, the user is able to pinpoint and mark individual stages of the dissolution procedure. Because of the unique camera position, different operations are well visible (tablet drop or basket immersion, sampling cannula or temperature probe immersion). The timing of different events can be determined down to seconds.

The dissoGUARD® PRO software is the ultimate guardian for your dissolution procedure and apparatus; it can alert the user of any abnormal status of these parameters during a test, preventing lost time and aiding in eventual failure investigations.

dissoGUARD® PRO is not meant to be a qualification tool, but it will keep you on the safe side during periodic OQ/ MQ measurements. With unique software algorithms, it can successfully predict excessive wobble for an individual basket or paddle. Measurement of individual paddle speed of rotation (rpm) is possible from the video itself. Proper centering of vessels and shafts can be checked. Software is able to warn a user about the status of a run. Once the system is installed, it will run almost automatically.

Without an analyst’s presence, strategically placed cameras and corresponding software can greatly improve monitoring of dissolution test conditions and/or potential failure analysis.

Specifically:

With an optional, easy-to-install amber shield around the bath and adaptive LED illumination (produces amber light), it is an ideal system to test light-sensitive products and prevent photodegradation of the active drug. The cameras deliver a solution for better visibility that eliminates the need for special laboratory lighting or other measures that would inhibit traditional observation of the amber dissolution vessels. An innovative homogenous illumination lighting system provides enough quality light for good quality videos for future post-processing.

Adding this capability to your laboratory dissolution environment offers important insight at each stage of the pharmaceutical product development process. Whether during formulation optimization, method development, or stability or routine QA/QC testing, observation and recording of the dissolution test itself provides an ideal mechanism for additional information gathering.

A system such as this could be utilized to evaluate how unexpected results are obtained, or periodically, to assess dosage form performance. Either way, failure investigations are expedited with an increasing amount of evidence available, and the dissolution data is enhanced with supplemental images or videos.

dissoGUARD® gives you a chance to perform dissolution tests with higher level of confidence.

For any further information, please contact us at:
Dissolution Accessories (a ProSense B.V. brand)
P.O. Box 173
4900 AD Oosterhout
The Netherlands
mail: info@dissolutionaccessories.com