2007 Issues

February 2007 Volume 14 Issue 1


Vibration Measurements on Dissolution Systems and Effects on Dissolution of Prednisone Tablets RS

Saroj Vangani,Tawnya Flick,Germinia Tamayo, Rick Chiu, and Nina Cauchon Small Molecule Pharmaceutics, Amgen Inc,Thousand Oaks, CA

In VitroñIn Vivo Correlation: Importance of Dissolution in IVIVC

J-M. Cardot, E. Beyssac, and M.Alric
Biopharmaceutical Department, UFR Pharmacie Clermont-Ferrand, France

Perturbation Study of Dissolution Apparatus VariablesóA Design of Experiment Approach

Joseph Eaton,Gang Deng,Walter W. Hauck, William Brown, Ronald G. Manning, and Samir Wahab
US Pharmacopeia, Rockville, MD

Evaluation of Glass Dissolution Vessel Dimensions and Irregularities

Mark R. Liddell,Gang Deng,Walter W. Hauck, William E. Brown, Samir Z.Wahab, and Ronald G. Manning
US Pharmacopeia, Rockville,MD

Dissolution Highlights of the AAPS Annual Meeting

Vivian Gray1 and Saji Thomas2
1Dissolution Technologies,Hockessin, DE
2Par Pharmaceuticals,Woodcliff Lake,NJ

Book Review: Injectable Dispersed Systems, Formulation, Processing and Performance Edited By Diane J. Burgess, Published by Taylor and Francis Group, Boca Raton FL, 2005 ISBN 0-8493-3699-6

Anne-FranÁoise Aubry, Ph.D. Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, NJ 08903

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD

May 2007 Volume 14 Issue 2


Commentaries on Mechanical versus Chemical Calibration

Contributing authors: Royal Hanson, Hanson Research; Saroj Vangani,Amgen; Alger Salt, GSK; John Burmicz, Pharma Test; Saji Thomas, Par Pharmaceutical, Jeff Seely,Distek; Johannes Kraemer, PHAST Laboratories, Jon Kretz,Watson Pharmaceuticals; and Bryan Crist,Varian

The Effects of Buffer Molarity,Agitation Rate, and Mesh Size on Verapamil Release from Modified- Release Mini-Tablets Using USP Apparatus 3

Sandile M. M. Khamanga and Roderick B.Walker
Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa

Application of USP Apparatus 7 to In Vitro Drug Release in Scopolamine Transdermal Systems

Marilyn X. Zhou,Duane Shoudt,Genaro Calderon, and Min Feng
Analytical Research and Development, Aveva Drug Delivery Systems,Miramar, FL

Attempt to Design Continuous DissolutionñAbsorption System Using Everted Intestine Segment for In Vitro Absorption Studies of Slow Drug Release Formulations

Vinita V. Kale, Rahul H. Kasliwal, and Jasmin G.Avari
Department of Pharmaceutical Sciences,
Rashtrasant Tukdoji Maharaj Nagpur University Campus, Maharashtra. India

Technical Note: Total Dissolved Gas Pressure (TDGP) Sensing in the Laboratory

Brian G.DíAoust
Common Sensing Inc., Clark Fork, ID

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD

August 2007 Volume 14 Issue 3


Proposed Change to Acceptance Criteria for Dissolution Performance Verification Testing

Walter W. Hauck, Ronald G. Manning, Todd L. Cecil, William Brown, Roger L. Williams
US Pharmacopeia, 12601 Twinbrook Parkway, Rockville, MD

Challenges with Dissolution Testing and Quality Assessment for Commercial Feverfew Products

Ping Jin1, Shadi Madieh2, and Larry L. Augsburger3
1United States Pharmacopeia, 12601 Twinbrook Parkway, Rockville, Maryland 20852, USA
2Glaxo Smith Kline, 709 Swedeland Road, King of Prussia, PA 19406, USA
3University of Maryland, Baltimore, School of Pharmacy, 20 N. Pine Street, Baltimore, MD 21201, USA

A Comparison of the Technical Quality of American and Japanese Ranitidine Tablets

Makoto Otsuka1, Yuka Akizuki2, Kuniko Otsuka3, Shinichiro Yanagisawa4, Isao Kamae4, and James A. Jorgenson5
1Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Shinmachi 1-1-20, Nishi-Tokyo, Tokyo 202-8585, Japan
2Kobe Pharmaceutical University, Motoyama-Kitamchi 4-19-1, Higashi-Nada, Kobe 658-8558, Japan
3School of Medicine, Showa University, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
4Faculty of Medicine, Kobe University, Kusunokichou 7-5-1, Chuo, Kobe 650-0017, Japan
5University Hospital Pharmacy, University of Utah, 50 North Medical Drive, Salt Lake City, Utah 84132, USA

Activities of the AAPS In Vitro Release and Dissolution Testing Focus Group

Kailas Thakker1 and Vivian Gray2
1Analytical Solutions, Durham, NC
2V.A. Gray Consulting, Hockessin, DE

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD

November 2007 Volume 14 Issue 4


Simplified Biorelevant Media for Screening Dissolution Performance of Poorly Soluble Drugs

Thomas Zoeller and Sandra Klein
Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main 60438, Germany

The Comparison of In Vitro Release Methods for the Evaluation of Oxytocin Release from PluronicÆ F127 Parenteral Formulations

F.A. Chaibva and R.B. Walker
Department of Pharmaceutics, Rhodes University, Grahamstown, South Africa, 6140

Differences in In Vitro Dissolution Rates Using Single-Point and Multi-Point Sampling

Limin Zhang1, Khanh Ha1, Brent Kleintop1, Shannon Phillips2, Barry Scheer1
1Analytical Research & Development, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ
2The Dow Chemical Company, Texas Operations, Freeport, TX

A Comparative In Vitro Assay of Drug Release Performance of Pyridostigmine Bromide Tablets

Noelia L. Gonzalez Vidal1,2, Patricia D. Zubata1, Laura D. Simionato1, Irma Ercolano1, and Maria T. Pizzorno1,2
1Cátedra Control de Calidad de Medicamentos, Facultad de Farmacia y Bioqu�mica, Universidad de Buenos Aires, Jun�n 956, 1113 Buenos Aires, Argentina
2Cátedra Control de Calidad de Medicamentos, Departamento de Biolog�a, Bioqu�mica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000 Bah�a Blanca, Argentina

Technical Note: Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine

Cynthia M. Berge1, Oksana Tsinman1, Dmytro Voloboy1, Dana Lipp1, Steven Stones2, and Alex Avdeef1
1pION INC, 5 Constitution Way, Woburn, MA 01801, USA
2Heath Scientific Co Ltd., Bletchley, MK1 1SW, UK

Meeting Report: AAPS/FDA Workshop on BE, BCS, and Beyond

Vivian Gray
V. A. Gray Consulting, Hockessin, DE

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD