2012 Issues

KinetDS: An Open Source Software for Dissolution Test Data Analysis

Aleksander Mendyk¹ , Renata Jachowicz¹, Kamil Fijorek², Przemysław Dorożyński¹, Piotr Kulinowski³, and Sebastian Polak^4
1Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University — Medical College, Kraków, Poland
²Department of Statistics, Faculty of Management, Kraków University of Economics, Kraków, Poland
³Institute of Technology, Pedagogical University, Kraków, Poland
⁴Unit of Pharmacoepidemiology and Pharmacoeconomics, Faculty of Pharmacy, Jagiellonian University — Medical College,Kraków, Poland

Dissolution Studies of Generic Medications: New Evidence of Deviations from the Transitivity Principle

M. Esperanza Ruiz¹, Anabella Gregorini¹, Alan Talevi², and Maria G. Volonté^1
1Quality Control of Medications, Department of Biological Sciences, Faculty of Exact Sciences, University of La Plata (UNLP), Buenos Aires, Argentina
²Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, University of La Plata (UNLP), Buenos Aires, Argentina

Toward Biorelevant Dissolution: Application of a Biphasic Dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II Drug

Daniel J. Phillips¹, Samuel R. Pygall², V. Brett Cooper², and James C. Mann^2
1Department of Chemistry, University of Warwick, UK
²Development Laboratories, MSD Development Laboratories, UK

Quality Control Studies on Conventional Carbamazepine Tablets Available in the Indian Drug Market

Kajal Ghosal, Subhash Ranu, Moktasd Billah, Sudhamoy Mondal, and Masudul Hoque
Dr. B. C. Roy College of Pharmacy and AHS, West Bengal, India

In Vitro Dissolution Kinetics of Captopril from Microspheres Manufactured by Solvent Evaporation

Sandile M. Khamanga and Roderick B. Walker
Faculty of Pharmacy, Rhodes University, South Africa

Mycophenolate Mofetil: Use of a Simple Dissolution Technique to Assess Generic Formulation Differences

Emmanuel Scheubel^1,2, Laurent Adamy², and Jean-Michel Cardot^1
1Biopharmaceutical Department, Faculty of Pharmacy, University of Auvergne Clermont-Ferrand, France
²F. Hoffmann-La Roche Ltd. Pharmaceutical Division, Galenical & Analytical Development Basel, Switzerland

Dissolution Profiles of Twelve Brands of Sulphadoxine Pyrimethamine in the Nigerian Market

N. A. Ochekpe¹, N. E. Ngwuluka¹, A. A. Agbowuro¹, and O. O. Obodozie^2
1Department of Pharmaceutical Chemistry, University of Jos, Jos, Nigeria
²National Institute for Pharmaceutical Research and Development, Abuja, Nigeria

Meeting Report: AAPS Workshop on "Dissolution Testing, Biowaivers and Bioequivalence" in Moscow, Russia

Vivian Gray
Dissolution Technologies, Hockessin, DE, USA

Meeting Report: AAPS Workshop on "Dissolution Testing, Biowaivers and Bioequivalence" in Zagreb, Croatia

Vivian Gray
Dissolution Technologies, Hockessin, DE, USA

Dissolution Highlights from the 2011 AAPS Annual Meeting in Washington, D. C.

Vivian Gray¹, Nikoletta Fotaki², and Gregory P. Martin^3
1V. A. Gray Consulting, Hockessin, DE, USA
²University of Bath, UK
³Complectors Consulting, Pottstown, PA, USA

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD

In Vitro Release Testing of PLGA Microspheres with Franz Diffusion Cells

Laura C. Herrera, Maria V. Defain Tesoriero, and Laura G. Hermida
Centre of Research and Development in Chemistry, National Institute of Industrial Technology, San Martin, Buenos Aires, Argentina

Evaluation of Cefixime-Loaded Chitosan Microspheres: Analysis of Dissolution Data Using DDSolver

Ghulam Murtaza¹, Mahmood Ahmad², Shujaat Ali Khan¹, and Izhar Hussain^1
1Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan
²Department of Pharmacy, Faculty of Pharmacy and Alternative Medicines, the Islamia University of Bahawalpur, Bahawalpur, Pakistan

Investigation of Furosemide Dialysis Rate in the Presence of Anionic Polymers

Parvin Zakei-Milani^1,2, Ziba Islambolchilar^3,4, Shole Ebrahimpoor^1,5, Mohammad Barzegar-Jalali¹, and Hadi Valizadeh^1,6
1Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
²Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
³Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
⁴Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
⁵Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
⁶Research Center for Pharmaceutical Nanotechnology, Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

The Use of Response Surface Methodology to Evaluate the Impact of Level 2 SUPAC—IR Changes on the In Vitro Release of Metronidazole and Ranitidine from a Fixed-Dose Combination Tablet

Loti D. Kingíori and Roderick B. Walker
Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa

Development of Discriminative Dissolution Media for Marketed Gliclazide Modified-Release Tablets

M. Bala Vishnu Priya and T. E. G. K. Murthy
Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur, Andhra Pradesh, India

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD

Effect of Various Operational Parameters on Drug Release from a 1% Hydrocortisone Semisolid Dosage Form Using the Vertical Diffusion Cell Apparatus

Loice Kikwai¹, Daren Tran², Walter W. Hauck², Vinod P. Shah², and Erika S. Stippler^2
1Food and Drug Administration, Rockville, MD, USA
²United States Pharmacopeial Convention, Rockville, MD, USA

The Design, Operation, and Application of a Dynamic Gastric Model

M. J. S. Wickham¹, R. M. Faulks², J. Mann³, and G. Mandalari^2
1Nutrition Research Department, Leatherhead Food Research, Leatherhead, Surrey, UK
²Model Gut Platform, Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
³MSD Development Laboratories, Hoddeston, Hertfordshire, UK

Dissolution Stability of Cephalexin Extemporaneous Suspensions During an Accelerated Stability Study

Marta I. V. Brevedan, María A. Varillas, and Noelia L. Gonzalez Vidal
Cátedra Control de Calidad de Medicamentos, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan, Bahía Blanca, Argentina

Development of a Discriminating In Vitro Dissolution Method for the Poorly Soluble Drug Rimonabant: Effect of Formulation Variables on Dosage Form Release Profiles

Felipe K. Hurtado, Aline Ravanello, Bruna G. S. Torres, Gabriele D. Souto, Ruy Carlos R. Beck, and Clarice M. B. Rolim
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil

Challenges in Dissolution Testing

Margareth R. C. Marques, William Brown, Gabriel Giancaspro, Natalia Davydova, Edith Chang, Jeanne Fringer, Walter Hauck, and Anthony DeStefano
U. S. Pharmacopeia, Rockville, MD, USA

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD

Permeation Kinetics Studies of Physical Mixtures of Artemisinin in Polyvinylpyrrolidone

Syed Nisar Hussain Shah¹, Yasser Shahzad², Muhammad Tayyab Ansari¹, Muhammad Haneef³,Madeeha Malik ³, Amir Badshah⁴, and Ghulam Murtaza^5
1Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
²Division of Pharmacy and Pharmaceutical Sciences, School of Applied Sciences, University of Huddersfield, UK
³SNS Pharmaceutical Research Laboratory, Multan, Pakistan
⁴Department of Pharmacy, Peshawar University, Peshawar, Pakistan
⁵Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan

A Formulation Case Study Comparing the Dynamic Gastric Model with Conventional Dissolution Methods

James C. Mann and Samuel R. Pygall
MSD Development Laboratories, Hoddesdon, Hertfordshire, UK

Effect of Formulation Variables on Dissolution of Water-Soluble Drug from Polyelectrolyte Complex Beads

M. A. Saleem^1,2, Divesh R Kotadia¹, and Raghavendra V. Kulkarni^3
1Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga, India
²Department of Biotechnology, Achariya Nagarjuna University, Nagarjuna Nagar, India
³Department of Pharmaceutical Technology, BLDEA's College of Pharmacy, Bijapur, India

Evaluation of In Vitro Equivalence for Tablets Containing the Poorly Water-Soluble Compound Atorvastatin

Farzana Akter Popy¹, Irin Dewan¹, Most. Nazma Parvin², and S. M. Ashraful Islam^1
1Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh
²Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh

Development and Validation of a Dissolution Method for Pioglitazone Tablets

A. P. Kulkarni, Mohd Shahnawaz, Zahid Zaheer, and M. H. G. Dehghan
Department of Quality Assurance, Dr. Maulana Azad Educational Trust's, Y. B. Chavan College of Pharmacy, Maharashtra, India

Comparison of Dissolution Profiles of Formulations Containing Ferrous Sulfate and Fumarate

S. Basualdo¹, H. Torti², J. Fuda², M. Nuñez³, and A. I. Segall^1
1Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
²Cátedra de Física, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
³Cátedra de Matemática, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

In Vitro Equivalence Studies of Generic Metformin Hydrochloride Tablets and Propranolol Hydrochloride Tablets Under Biowaiver Conditions in Lagos State, Nigeria

Olubukola O. Oyetunde¹, Fola Tayo¹, Moshood O. Akinleye², and Bolajoko A. Aina^1
1Department of Clinical Pharmacy & Biopharmacy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria
²Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria

Meeting Report: PQRI Workshop on Application of IVIVC in Formulation Development

Vivian Gray
Dissolution Technologies, Hockessin, DE, USA

Question & Answer Section

Margareth Marques and William Brown
United States Pharmacopeia, Rockville,MD