Somerset, NJ—July 5, 2016—With a large array of products, Logan Instruments Corp. has further improved upon its latest suspension system with a switchable dry-heat compartment. The Logan dry-heat temperature-controlling system maintains a preset temperature, typically 37 °C, with the use of thermostatically controlled heater blocks surrounding the flow-through cells. The dry-heat compartment can operate in a vertical position for USP 4 Type A and Type B cells. It also operates in a horizontal position for suspension cells. This system uses a flow-through method, which is accomplished with a dual syringe pump system. The dual syringe pump system provides constant flow at 4, 8, and 16 mL/min selectable as per USP 4 guidelines.

The Logan SUS-4000 operates on the same principle as a traditional USP 4 in which the Type A/B cells are in a vertical position. However, the Logan SUS-4000 has the “Tower Filter” design that limits filter clogging and ensures no leaking tubes.

For suspension drugs, the dry-heat compartment for cells switches to a horizontal position and operates as follows: A membrane is mounted between the suspension cell (donor) and the flowthrough chamber (receptor). The drug is distributed to the membrane by homogenous agitation, allowing the drug to penetrate the membrane, and is collected by the flow-through medium. After mixing, the samples are collected into tubes/vials for further analysis.

This new automated system tests the suspension samples in a “flowthrough suspension cell” instead of the traditional USP Methods I and II, collecting up to 60 sample time points.The dual syringe pump module constantly withdraws preheated medium from the reservoir and passes it through the cells. The medium mixes with the released drugs, and then mixes again in a delivery loop. The sets of precise volume samples are then automatically delivered into HPLC vials or glass tubes simultaneously, where there is no buildup of pressure in the system and no leakage. The samples can run in a closed or open loop. A printer will also be available to document the system test.

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