Simulations Plus Releases GastroPlus Version 9.6

Significant improvements support internal research activities through regulatory interactions

Lancaster, CA—April 5, 2017—Simulations Plus, Inc. (Nasdaq: SLP), the leading provider of modeling and simulation solutions for the pharmaceutical, biotechnology, and chemicals industries, has released version 9.6 of its flagship physiologically-based pharmacokinetic (PBPK) modeling program, Gas troPlus™.

Key improvements include:

Dr. Viera Lukacova, Director of Simulation Sciences, said: “This version of GastroPlus provides new features that users have requested and will appreciate. It is the product of ongoing input and collaboration with the US FDA, industry, academics, and by our talented Simulations Plus’ and DILIsym® Services scientific teams.

John DiBella, President of Lancaster division, added: “GastroPlus continues to be the mostly widely used commercial PBPK software worldwide, and this new release is the most feature-rich and user-friendly in our history. With the everincreasing emphasis on PBPK modeling from regulatory agencies globally, the client base for GastroPlus continues to expand. For over 20 years, our company has invested to improve our software tools and attract the most talented scientists, and this will continue as we look to meet the unprecedented demand for PBPK modeling support and new functionality requests.”

About Simulations Plus, Inc.

Simulations Plus, Inc. is a premier developer of drug discovery and development software as well as a leading provider of both preclinical and clinical pharmacometric consulting services for regulatory submissions and quantitative systems pharmacology models for drug-induced liver injury and nonalcoholic fatty liver disease. The company is a global leader focused on improving the ways scientists use knowledge and data to predict the properties and outcomes of pharmaceutical, biotechnology, and chemical agents. Our software is licensed to and used in the conduct of drug research by major pharmaceutical, biotechnology, chemical, and consumer goods companies and regulatory agencies worldwide. Our innovations in integrating new and existing science in medicinal chemistry, computational chemistry, pharmaceutical science, biology, and physiology into our software have made us the leading software provider for physiologically based pharmacokinetic modeling and simulation. For more information, visit our website at