Logan’s 3-in-1 Automated Dissolution Permeation (ADSP) System

Logan Instruments is proud to announce its newest innovation is a 3-in-1 system: Automated Dissolution Solubility Permeation (ADSP) system, designed to improve efficiency and accelerate development for pharmaceutical R&D. The ADSP system seamlessly integrates the automated dissolution system, automated solubility testing system, and permeation/absorption system. It has online UV detection and data analytic capabilities. The analysis software runs through the Windows operating system.

The solubility profile for the APIs in different dosage forms is achieved by the Logan STL-100, where the APIs can be determined at six different pH and/or six different temperatures simultaneously. Each solvent and temperature can be changed by the user in six different sample tubes. The system comes with an optional filter system to eliminate undissolved particles. It also provides the accessories to consolidate the API powder to extend the solubility time.

The APIs permeation and/or absorption is tested by using the Logan permeation cells system. This system uses a unique dual cell design, holding an API solution on one side and a receptor solution on the other with a permeation membrane between them. The receptor solution is constantly transferred into a UV spectrum photometer which gives absorbance readout to provide the information of API absorbed by the human body.

After the tablet is formed, the dissolution evaluation is tested using our universal dissolution system. The system contains 8 or 12 vessels that are designed for simultaneous testing for automated dissolution evaluation. The no-vibration and selfcalibrating design ensure all tablets dissolve at the speed and temperature the user prefers. A syringe pump and a UV analysis system are attached to the system, designed to analyze the dissolution samples.

The Logan PERMETRO system is used to test the absorption of the tablet in the human body. This system uses a unique dual cell design which holds an API solution on one side and a receptor solution on the other. A permeation membrane is held between the dual cell, and the receptor solution is constantly transferred into the UV spectrum photometer for reading.

The ADSP is the automated all-in-one system designed for pharmaceutical R&D needs in solubility, permeation, and dissolution. The ADSP is in full compliance with 21 CFR part 11 and fully meets GLP requirements. For more information, please contact Logan Instruments.

For more information contact info@loganinstruments.com.